English
norskBlar i forfatter "Figenschau, Yngve Anton"
Viser treff 1-10 av 10
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Co-expression of 1α-hydroxylase and vitamin D receptor in human articular chondrocytes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-06)Background: <br> The aim was to investigate whether resident chondrocytes in human articular cartilage and in subculture express vitamin D receptor (VDR) and the enzyme that hydroxylates the prohormone 25(OH)D3 to the active hormone 1α,25(OH)2D3, namely 1α-hydroxylase (CYP27B1). Any putative effects of vitamin D on chondrocytes were also explored. <br> Methods: <br> Cartilage from human osteoarthritic ... -
Cortisol levels and cognitive profile in major depression: A comparison of currently and previously depressed patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-22)The association between depressive symptoms and elevated cortisol levels, and depression and cognitive functioning, has been less robust in outpatients with symptoms in the mild to moderate range. Furthermore, the association between elevated cortisol levels and cognitive functioning is unclear. In the present study, currently depressed (<i>n</i> = 37), previously depressed (<i>n</i> = 81) and never ... -
Dynamic expression of VDR and 1-alpha-hydroxylase in differentiated and re-differentiated human articular chondrocytes
(Conference object; Konferansebidrag, 2016-09)<p><i>Purpose:</i> The goal was to investigate potential roles played by vitamin D in the regulation of joint cartilage biology. We studied the expression of two central elements of vitamin D metabolism, namely the vitamin D receptor and its converting enzyme 1αhydroxylase in human knee cartilage and chondrocytes. <p><i>Methods and Materials:</i> Expression of receptor and enzyme was determined ... -
Effects of Age and Sex on Estimated Diabetes Prevalence Using Different Diagnostic Criteria: The Tromso OGTT Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Hb 6.5% has recently been recommended as an alternative diagnostic criterion for diabetes. The aims of the study were to evaluate the effects of age, sex, and other factors on prevalence of diabetes and to compare risk profiles of subjects with diabetes when defined by Hb and glucose criteria. Subjects were recruited among participants in the longitudinal population-based Tromsø Study. Hb , fasting ... -
Effects of Vitamin D binding protein phenotypes and Vitamin D supplementation on serum total 25(OH)D and directly measured free 25(OH)D
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-01-05)Objective:<br>To determine the relationship between serum total 25-hydroxyvitamin D (25(OH)D), directly measured free 25(OH)D and calculated free 25(OH)D with regard to vitamin D-binding protein (DBP) phenotypes, sex, BMI, age and season, and their interrelationship to vitamin D supplementation.<br>Design, patients and interventions:<br>A randomized controlled trial with 20 000 IU of vitamin D3 per ... -
Expression and function of Leukotriene B4 receptors in human articular chondrocytes
(Conference object; Konferansebidrag, 2013)Leukotriene B4 (LTB4) is linked to osteoarthritis (OA) development however the expression of LTB4 receptors in cartilage cells and the physiological effects of LTB4 on cartilage tissue remain unknown. In this study we find that human articular chondrocytes express LTB4 receptors and that these receptors are functional, however, LTB4 does not seem to affect importantly some primary chondrocyte functions. -
Failure to Find a Conditioned Placebo Analgesic Response
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-30)<p><i>Background</i>: Associative learning has, in several studies, been modulated by the sex of the participant. Consistent with this, a recent review found that conditioned nocebo effects are stronger in females than in males.</p> <p><i>Purpose</i>: It has been suggested that conditioned placebo responses are stronger in females, and this hypothesis was investigated in the present study. Cortisol ... -
Human articular chondrocytes express functional Leukotriene B4 receptors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-09)Leukotriene B<sub>4</sub> (LTB<sub>4</sub>) is a potent chemoattractant associated with the development of osteoarthritis (OA), while its receptors BLT1 and BLT2 have been found in synovium and subchondral bone. In this study, we have investigated whether these receptors are also expressed by human cartilage cells and their potential effects on cartilage cells. The expression of LTB<sub>4</sub> ... -
The phosphodiesterase 8B gene rs4704397 is associated with thyroid function, risk of myocardial infarction and body height. The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)Objective: High serum thyrotropin (TSH) levels predict cardiovascular disease (CVD). Recently several single nucleotide polymorphisms (SNPs) associated with TSH levels have been identified, one of them being the rs4704397 SNP in the phosphodiesterase 8B (PDE8B) gene. If the relation between thyroid function and CVD is causal, one could also expect rs4704397 genotypes to predict CVD and possibly ... -
The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-18)Background: Formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor mainly expressed by the cells of myeloid origin, where it mediates the innate immune response to bacterial formylated peptides. High expression of FPR1 has been detected in various cancers but the function of FPR1 in tumorigenesis is poorly understood. Methods: Expression of FPR1 in neuroblastoma cell lines and primary ...
